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TargetApoptosis regulator Bcl-XL
LigandBDBM178877
Substrate/Competitorn/a
Meas. Tech.Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) Assay
Ki 17.841±n/a nM
Citation Bruncko, MDing, HDoherty, GAElmore, SWHasvold, LHexamer, LAKunzer, ARMantei, RAMcClellan, WJPark, CHPark, CPetros, AMSong, XSouers, AJSullivan, GMTao, ZWang, GTWang, LWang, XWendt, MD Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases US Patent US9125913 Publication Date 9/8/2015
More Info.:Get all data from this article,  Assay Method
 
Apoptosis regulator Bcl-XL
Name:Apoptosis regulator Bcl-XL
Synonyms:n/a
Type:Protein
Mol. Mass.:26122.63
Organism:Mus musculus (Mouse)
Description:Q64373
Residue:233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEETEAERETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIASWMATYLNDHLEP
WIQENGGWDTFVDLYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM178877
NameBDBM178877
Synonyms:US9125913, 449
TypeSmall organic molecule
Emp. Form.C46H52Cl2N8O4S
Mol. Mass.883.927
SMILESCC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3cnc(NC4CCN(CC4)C4CC4)c(Cl)c3)c(Oc3cccc4[nH]cnc34)c2)=C(C1)c1ccc(Cl)cc1 |c:58|
Structure
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n/a