Target
Alpha-glucosidase MAL12
Ligand
BDBM181062
Substrate
n/a
Meas. Tech.
In vitro Assay of alpha-Glucosidasee Inhibitory Activity
pH
6.8±n/a
IC50
6.24e+3± 7e+1 nM
Comments
extracted
Citation
 Wang, GHe, DLi, XLi, JPeng, Z Design, synthesis and biological evaluation of novel coumarin thiazole derivatives as a-glucosidase inhibitors. Bioorg Chem 65:167-74 (2016) [PubMed]  Article 
Target
Name:
Alpha-glucosidase MAL12
Synonyms:
α-Glucosidase | MAL12 | MAL12_YEAST | MAL1S | Maltase | alpha-Glucosidase (α-Glucosidase)
Type:
Protein
Mol. Mass.:
68084.32
Organism:
Saccharomyces cerevisiae
Description:
P53341
Residue:
584
Sequence:
MTISDHPETEPKWWKEATIYQIYPASFKDSNNDGWGDLKGITSKLQYIKDLGVDAIWVCPFYDSPQQDMGYDISNYEKVWPTYGTNEDCFELIDKTHKLGMKFITDLVINHCSTEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSFFGGSAWTFDETTNEFYLRLFASRQVDLNWENEDCRRAIFESAVGFWLDHGVDGFRIDTAGLYSKRPGLPDSPIFDKTSKLQHPNWGSHNGPRIHEYHQELHRFMKNRVKDGREIMTVGEVAHGSDNALYTSAARYEVSEVFSFTHVEVGTSPFFRYNIVPFTLKQWKEAIASNFLFINGTDSWATTYIENHDQARSITRFADDSPKYRKISGKLLTLLECSLTGTLYVYQGQEIGQINFKEWPIEKYEDVDVKNNYEIIKKSFGKNSKEMKDFFKGIALLSRDHSRTPMPWTKDKPNAGFTGPDVKPWFLLNESFEQGINVEQESRDDDSVLNFWKRALQARKKYKELMIYGYDFQFIDLDSDQIFSFTKEYEDKTLFAALNFSGEEIEFSLPREGASLSFILGNYDDTDVSSRVLKPWEGRIYLVK
  
Inhibitor
Name:
BDBM181062
Synonyms:
(E)-N'-(3,5-Dichloro-2-hydroxybenzylidene)-4-(2-oxo-2Hchromen-3-yl)thiazole-2-carbohydrazide (7e)
Type:
Small organic molecule
Emp. Form.:
C20H11Cl2N3O4S
Mol. Mass.:
460.29
SMILES:
Oc1c(Cl)cc(Cl)cc1\C=N\NC(=O)c1nc(cs1)-c1cc2ccccc2oc1=O
Structure:
Search PDB for entries with ligand similarity: