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Target
Alpha-glucosidase MAL12
Ligand
BDBM181065
Substrate
n/a
Meas. Tech.
In vitro Assay of alpha-Glucosidasee Inhibitory Activity
pH
6.8±n/a
IC50
2.990e+4± 4.6e+2 nM
Comments
extracted
Citation
 Wang, G; He, D; Li, X; Li, J; Peng, Z Design, synthesis and biological evaluation of novel coumarin thiazole derivatives as a-glucosidase inhibitors. Bioorg Chem 65:167-74 (2016) [PubMed]  Article 
Target
Name:
Alpha-glucosidase MAL12
Synonyms:
α-Glucosidase | MAL12 | MAL12_YEAST | MAL1S | Maltase | alpha-Glucosidase (α-Glucosidase)
Type:
Protein
Mol. Mass.:
68084.32
Organism:
Saccharomyces cerevisiae
Description:
P53341
Residue:
584
Sequence:
MTISDHPETEPKWWKEATIYQIYPASFKDSNNDGWGDLKGITSKLQYIKDLGVDAIWVCPFYDSPQQDMGYDISNYEKVWPTYGTNEDCFELIDKTHKLGMKFITDLVINHCSTEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSFFGGSAWTFDETTNEFYLRLFASRQVDLNWENEDCRRAIFESAVGFWLDHGVDGFRIDTAGLYSKRPGLPDSPIFDKTSKLQHPNWGSHNGPRIHEYHQELHRFMKNRVKDGREIMTVGEVAHGSDNALYTSAARYEVSEVFSFTHVEVGTSPFFRYNIVPFTLKQWKEAIASNFLFINGTDSWATTYIENHDQARSITRFADDSPKYRKISGKLLTLLECSLTGTLYVYQGQEIGQINFKEWPIEKYEDVDVKNNYEIIKKSFGKNSKEMKDFFKGIALLSRDHSRTPMPWTKDKPNAGFTGPDVKPWFLLNESFEQGINVEQESRDDDSVLNFWKRALQARKKYKELMIYGYDFQFIDLDSDQIFSFTKEYEDKTLFAALNFSGEEIEFSLPREGASLSFILGNYDDTDVSSRVLKPWEGRIYLVK
  
Inhibitor
Name:
BDBM181065
Synonyms:
(E)-N'-(2-Hydroxy-4-methoxybenzylidene)-4-(2-oxo-2Hchromen-3-yl)thiazole-2-carbohydrazide (7i)
Type:
Small organic molecule
Emp. Form.:
C21H15N3O5S
Mol. Mass.:
421.426
SMILES:
COc1ccc(\C=N\NC(=O)c2nc(cs2)-c2cc3ccccc3oc2=O)c(O)c1
Structure:
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