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Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM184631
Substrate
n/a
Meas. Tech.
Radioligand Binding
pH
7.4±n/a
Temperature
277.15±n/a K
IC50
20±n/a nM
EC50
0.3±n/a nM
Comments
extracted
Citation
 Donde, Y; Nguyen, JH; Kedzie, KM; Gil, DW; Donello, JE; Im, W Treatment of inflammatory bowel disease US Patent  US9156810 Publication Date 10/13/2015 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Homo sapiens (Human)
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM184631
Synonyms:
US9156810, (54, 55)
Type:
Small organic molecule
Emp. Form.:
C26H32O5S
Mol. Mass.:
456.594
SMILES:
CC1(C)[C@@H](O)[C@H](\C=C\C(O)Cc2cc3ccccc3s2)[C@@H](C\C=C/CCCC(O)=O)C1=O
Structure:
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