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TargetFerrochelatase R115L (FECH)
LigandBDBM50429701
Substrate/Competitorn/a
Meas. Tech.Competition Binding Assays
Kd 3.4e+3± 0 nM
Citation Klaeger, SGohlke, BPerrin, JGupta, VHeinzlmeir, SHelm, DQiao, HBergamini, GHanda, HSavitski, MMBantscheff, MMédard, GPreissner, RKuster, B Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors. ACS Chem Biol11:1245-54 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Ferrochelatase R115L (FECH)
Name:Ferrochelatase R115L (FECH)
Synonyms:n/a
Type:Protein
Mol. Mass.:47832.73
Organism:Homo sapiens (Human)
Description:Mutant R115L used for experiment
Residue:423
Sequence:
MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQV
QPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRLTPKIQ
EQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERD
GLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADH
ILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLV
WQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKEC
GVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTS
QQL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50429701
n/a
NameBDBM50429701
Synonyms:AZD-2014 | CHEMBL2336325 | US9102670, 1ap
TypeSmall organic molecule
Emp. Form.C25H30N6O3
Mol. Mass.462.5441
SMILESCNC(=O)c1cccc(c1)-c1ccc2c(nc(nc2n1)N1CCOC[C@@H]1C)N1CCOC[C@@H]1C |r|
Structure
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