Reaction Details Report a problem with these data
Target
Ferrochelatase, mitochondrial [R115L]
Ligand
BDBM185149
Substrate
n/a
Meas. Tech.
Competition Binding Assays
Kd
3.8e+3±n/a nM
Citation
 Klaeger, S; Gohlke, B; Perrin, J; Gupta, V; Heinzlmeir, S; Helm, D; Qiao, H; Bergamini, G; Handa, H; Savitski, MM; Bantscheff, M; Médard, G; Preissner, R; Kuster, B Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors. ACS Chem Biol 11:1245-54 (2016) [PubMed]  Article 
Target
Name:
Ferrochelatase, mitochondrial [R115L]
Synonyms:
FECH | Ferrochelatase R115L (FECH) | HEMH_HUMAN
Type:
Protein
Mol. Mass.:
47832.73
Organism:
Homo sapiens (Human)
Description:
Mutant R115L used for experiment
Residue:
423
Sequence:
MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQVQPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRLTPKIQEQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADHILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLVWQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKECGVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTSQQL
  
Inhibitor
Name:
BDBM185149
Synonyms:
1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol-1-yl]quinolin-8-yl]piperidin-4-amine | Crenolanib | US11542261, Compound crenolanib
Type:
Small organic molecule
Emp. Form.:
C26H29N5O2
Mol. Mass.:
443.5408
SMILES:
CC1(COc2ccc3n(cnc3c2)-c2ccc3cccc(N4CCC(N)CC4)c3n2)COC1
Structure:
Search PDB for entries with ligand similarity: