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TargetAdenosine receptor A1
LigandBDBM191816
Substrate/Competitorn/a
Meas. Tech.Luciferase Assay
pH7.4±n/a
Temperature310.15±n/a K
EC50 0.4±n/a nM
Commentsextracted
Citation Vakalopoulos, AMeibom, DNell, PSussmeier, FAlbrecht-Kupper, BZimmermann, KKeldenich, JSchneider, DKrenz, U Substituted dicyanopyridines and use thereof US Patent US9187428 Publication Date 11/17/2015
More Info.:Get all data from this article,  Assay Method
 
Adenosine receptor A1
Name:Adenosine receptor A1/Alpha-2A adrenergic receptor
Synonyms:A1 adenosine receptor (hA1) | A1AR | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:36520.92
Organism:Homo sapiens (Human)
Description:P30542
Residue:326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVT
PRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPAPPIDEDLPEERPDD
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  Blast E-value cutoff:
BDBM191816
NameBDBM191816
Synonyms:US9187428, 44
TypeSmall organic molecule
Emp. Form.C23H20N6O3S
Mol. Mass.460.508
SMILESCNC(=O)c1cc(CSc2nc(N)c(C#N)c(-c3ccc(OC)cc3OC)c2C#N)ccn1 |(7.34,-5.39,;7.34,-3.85,;6,-3.08,;6,-1.54,;4.67,-3.85,;3.33,-3.08,;2,-3.85,;.67,-3.08,;-.67,-3.85,;-2,-3.08,;-3.33,-3.85,;-4.67,-3.08,;-6,-3.85,;-4.67,-1.54,;-6,-.77,;-7.34,,;-3.33,-.77,;-3.33,.77,;-4.67,1.54,;-4.67,3.08,;-3.33,3.85,;-3.33,5.39,;-2,6.16,;-2,3.08,;-2,1.54,;-.67,.77,;.67,1.54,;-2,-1.54,;-.67,-.77,;.67,,;2,-5.39,;3.33,-6.16,;4.67,-5.39,)|
Structure
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