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Target5'-AMP-activated protein kinase catalytic subunit alpha-1
LigandBDBM192509
Substrate/Competitorn/a
Meas. Tech.AMPK Activation Assay
pH7±n/a
EC50 119±n/a nM
Citation Wagner, HHimmelsbach, F Azabenzimidazole derivatives US Patent US9187477 Publication Date 11/17/2015
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
5'-AMP-activated protein kinase catalytic subunit alpha-1
Name:5'-AMP-activated protein kinase catalytic subunit alpha-1
Synonyms:5''-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKa1) | 5''-AMP-activated protein kinase subunit alpha-1 | ACACA kinase | AMP-activated protein kinase, alpha-1 subunit | AMPK subunit alpha-1 | AMPK-alpha1 | Hydroxymethylglutaryl-CoA reductase kinase | Tau-protein kinase PRKAA1
Type:Protein
Mol. Mass.:64023.62
Organism:Homo sapiens (Human)
Description:Q13131
Residue:559
Sequence:
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR
QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG
RLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF
LRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDG
IFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMID
DEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDS
FLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDI
MAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDE
ITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPG
SHTIEFFEMCANLIKILAQ
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BDBM192509
NameBDBM192509
Synonyms:US9187477, 5
TypeSmall organic molecule
Emp. Form.C30H35ClN4O7
Mol. Mass.599.075
SMILESO[C@@H]1COC2[C@@H](COC12)Oc1nc2cc(Cl)c(nc2[nH]1)-c1ccc(cc1)[C@@H]1CC[C@@H](CC1)NC(=O)OC1CCOCC1 |r,wU:26.30,5.10,1.0,29.37,(12.5,-7.38,;11.73,-6.05,;12.21,-4.58,;10.96,-3.68,;9.72,-4.58,;8.18,-4.58,;7.7,-6.05,;8.95,-6.95,;10.19,-6.05,;7.41,-3.25,;5.87,-3.25,;4.96,-4.49,;3.5,-4.02,;2.17,-4.79,;.83,-4.02,;-.5,-4.79,;.83,-2.48,;2.17,-1.71,;3.5,-2.48,;4.96,-2,;-.5,-1.71,;-.5,-.17,;-1.84,.6,;-3.17,-.17,;-3.17,-1.71,;-1.84,-2.48,;-4.5,.6,;-4.5,2.14,;-5.84,2.91,;-7.17,2.14,;-7.17,.6,;-5.84,-.17,;-8.5,2.91,;-9.84,2.14,;-9.84,.6,;-11.17,2.91,;-11.17,4.45,;-12.5,5.22,;-12.5,6.76,;-11.17,7.53,;-9.84,6.76,;-9.84,5.22,)|
Structure
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