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Target5'-AMP-activated protein kinase catalytic subunit alpha-1
LigandBDBM192512
Substrate/Competitorn/a
Meas. Tech.AMPK Activation Assay
pH7±n/a
EC50 339±n/a nM
Citation Wagner, HHimmelsbach, F Azabenzimidazole derivatives US Patent US9187477 Publication Date 11/17/2015
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
5'-AMP-activated protein kinase catalytic subunit alpha-1
Name:5'-AMP-activated protein kinase catalytic subunit alpha-1
Synonyms:5''-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKa1) | 5''-AMP-activated protein kinase subunit alpha-1 | ACACA kinase | AMP-activated protein kinase, alpha-1 subunit | AMPK subunit alpha-1 | AMPK-alpha1 | Hydroxymethylglutaryl-CoA reductase kinase | Tau-protein kinase PRKAA1
Type:Protein
Mol. Mass.:64023.62
Organism:Homo sapiens (Human)
Description:Q13131
Residue:559
Sequence:
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR
QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG
RLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF
LRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDG
IFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMID
DEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDS
FLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDI
MAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDE
ITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPG
SHTIEFFEMCANLIKILAQ
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BDBM192512
NameBDBM192512
Synonyms:US9187477, 8
TypeSmall organic molecule
Emp. Form.C28H33ClN4O6
Mol. Mass.557.038
SMILESCC(C)NC(=O)O[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1nc2[nH]c(O[C@@H]3COC4[C@H](O)COC34)nc2cc1Cl |r,wU:10.13,25.26,29.31,wD:7.6,(-12.36,6.35,;-11.03,5.58,;-9.69,6.35,;-11.03,4.04,;-9.69,3.27,;-9.69,1.73,;-8.36,4.04,;-7.03,3.27,;-7.03,1.73,;-5.69,.96,;-4.36,1.73,;-4.36,3.27,;-5.69,4.04,;-3.31,1.01,;-1.98,1.78,;-.65,1.01,;-.65,-.53,;-1.98,-1.3,;-3.31,-.53,;.69,-1.3,;2.02,-.53,;3.35,-1.3,;4.82,-.82,;5.72,-2.07,;7.26,-2.07,;8.03,-3.4,;7.56,-4.87,;8.8,-5.77,;10.05,-4.87,;11.59,-4.87,;12.36,-6.2,;12.07,-3.4,;10.82,-2.5,;9.57,-3.4,;4.82,-3.31,;3.35,-2.84,;2.02,-3.61,;.69,-2.84,;-.65,-3.61,)|
Structure
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