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Target
Tyrosine-protein kinase JAK3 [781-1124]
Ligand
BDBM192809
Substrate
n/a
Meas. Tech.
Phosphorylation Assay
pH
7.5±n/a
Temperature
25±n/a K
IC50
0.2±n/a nM
Citation
 Goldstein, DM; Brameld, KA; Verner, E Azaindole derivatives as tyrosine kinase inhibitors US Patent  US9187487 Publication Date 11/17/2015 
Target
Name:
Tyrosine-protein kinase JAK3 [781-1124]
Synonyms:
JAK3 | JAK3 (aa 781-1124) | JAK3_HUMAN | Janus kinase 3 (JAK3) | Tyrosine-protein kinase JAK3 | Tyrosine-protein kinase JAK3 (781-1124) | Tyrosine-protein kinase JAK3 (aa 781-1124)
Type:
n/a
Mol. Mass.:
38772.27
Organism:
Homo sapiens (Human)
Description:
P52333[781-1124]
Residue:
344
Sequence:
ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
  
Inhibitor
Name:
BDBM192809
Synonyms:
US9187487, 71
Type:
Small organic molecule
Emp. Form.:
C23H25N7O2
Mol. Mass.:
431.4903
SMILES:
CN(C)C(=O)C(=Cc1ccc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)cc1)C#N |w:6.6|
Structure:
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