Reaction Details Report a problem with these data
Target
Lysosomal Pro-X carboxypeptidase
Ligand
BDBM193283
Substrate
n/a
Meas. Tech.
Activation Assay
Ki
5.657e+5±n/a nM
Citation
 Shariat-Madar, Z; Rimoldi, JM; Gadepalli, RS Selective inhibitors of prolylcarboxypeptidase US Patent  US9193762 Publication Date 11/24/2015 
Target
Name:
Lysosomal Pro-X carboxypeptidase
Synonyms:
Angiotensinase C | Lysosomal carboxypeptidase C | PCP | PCP_HUMAN | PRCP | Proline carboxypeptidase | Prolylcarboxypeptidase | Prolylcarboxypeptidase (PRCP)
Type:
Enzyme
Mol. Mass.:
55805.19
Organism:
Homo sapiens (Human)
Description:
P42785
Residue:
496
Sequence:
MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHFGFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH
  
Inhibitor
Name:
BDBM193283
Synonyms:
US9193762, RS-37-02
Type:
Small organic molecule
Emp. Form.:
C24H28ClN3O4
Mol. Mass.:
457.95
SMILES:
Clc1cccc(CNC(=O)CCCNC(=O)[C@@H]2CCCN2C(=O)OCc2ccccc2)c1 |r|
Structure:
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