Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [44-168]
Ligand
BDBM193889
Substrate
n/a
Meas. Tech.
BRD4-BD1 Binding Assay
Temperature
298.15±n/a K
IC50
6.5e+2± 21 nM
Comments
extracted
Citation
 Yang, Y; Zhao, L; Xu, B; Yang, L; Zhang, J; Zhang, H; Zhou, J Design, synthesis and biological evaluation of dihydroquinoxalinone derivatives as BRD4 inhibitors. Bioorg Chem 68:236-44 (2016) [PubMed]  Article 
Target
Name:
Bromodomain-containing protein 4 [44-168]
Synonyms:
BET bromodomain 4(1) (BRD4(1)) | BRD4 | BRD4-BD1 protein (aa 44-168) | BRD4_HUMAN | Bromodomain protein 4 (BRD4-BD1) | Bromodomain-containing protein 4 (BRD4-BD1) | Bromodomain-containing protein 4 (BRD4) (aa 44-168) | Bromodomain-containing protein 4 (BRD4-BD1) | Bromodomain-containing protein 4 bromodomain 1 (BRD4-BD1) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14866.49
Organism:
Homo sapiens (Human)
Description:
aa (44-168)
Residue:
125
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
  
Inhibitor
Name:
BDBM193889
Synonyms:
8(R)-4-benzyl-6-(3,5-dimethylisoxazol-4-yl)-3-(hydroxymethyl)-3,4-dihydroquinoxalin-2(1H)-one (5h)
Type:
Small organic molecule
Emp. Form.:
C21H21N3O3
Mol. Mass.:
363.4097
SMILES:
Cc1noc(C)c1-c1ccc2NC(=O)C(CO)N(Cc3ccccc3)c2c1
Structure:
Search PDB for entries with ligand similarity: