Reaction Details Report a problem with these data
Target
Nitric oxide synthase oxygenase [E25A,E26A,I218V,E316A]
Ligand
BDBM14322
Substrate
n/a
Meas. Tech.
bBiDomain assay
IC50
6.39e+4±n/a nM
Citation
 Holden, JK; Lewis, MC; Cinelli, MA; Abdullatif, Z; Pensa, AV; Silverman, RB; Poulos, TL Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-Based Inhibitors. Biochemistry 55:5587-5594 (2016) [PubMed]  Article 
Target
Name:
Nitric oxide synthase oxygenase [E25A,E26A,I218V,E316A]
Synonyms:
NOSO_BACSU | Nitric Oxide Synthase I218V | bNOS | nos | yflM
Type:
n/a
Mol. Mass.:
41707.55
Organism:
Bacillus subtilis
Description:
5G6P
Residue:
363
Sequence:
MEEKEILWNEAKAFIAACYQELGKAAEVKDRLADIKSEIDLTGSYVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATNNGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGWRGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPIVSDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLWKDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQAEEAGRKLTGDWTWLIPPISPAATHIFHRSYDNSIVKPNYFYQDKPYE
  
Inhibitor
Name:
BDBM14322
Synonyms:
2-Aminoquinoline 1 | 2-aminoquinoline | CHEMBL61236 | Fragment 19 | Quinolin-2-amine | fragment 2 (J. med. chem.,50,1116)
Type:
Small organic molecule
Emp. Form.:
C9H8N2
Mol. Mass.:
144.1732
SMILES:
Nc1ccc2ccccc2n1
Structure:
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