Reaction Details Report a problem with these data
Target
72 kDa type IV collagenase
Ligand
BDBM199124
Substrate
n/a
Meas. Tech.
enzyme-based fluorimetric assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
18.58±0.67 nM
Comments
extracted
Citation
 Zheng, XZ; Zhou, JL; Ye, J; Guo, PP; Lin, CS Cardioprotective effect of novel sulphonamides-1,3,5-triazine conjugates against ischaemic-reperfusion injury via selective inhibition of MMP-9. Chem Biol Drug Des 88:756-765 (2016) [PubMed]  Article 
Target
Name:
72 kDa type IV collagenase
Synonyms:
72 kDa type IV collagenase | MMP2_RAT | Matrix metalloproteinase-2 (MMP-2) | Mmp2
Type:
n/a
Mol. Mass.:
74137.51
Organism:
Rattus norvegicus (Rat)
Description:
P33436
Residue:
662
Sequence:
MEARLVWGVLVGPLRVLCVLCCLLGHAIAAPSPIIKFPGDVSPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARALKVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGREYSSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNGDGQPCKFPFRFQGTSYNSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKVWCATTTNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSNDDIKGIQELYGPSPDADTDTGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSLGLPPDVQQVDAAFNWSKNKKTYIFSGDKFWRYNEVKKKMDPGFPKLIADSWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
  
Inhibitor
Name:
BDBM199124
Synonyms:
N-(4-(1-(4,6-bis((4-methoxyphenyl)amino)-1,3,5-triazin-2-yl)-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)phenyl)-4-methylbenzenesulphonamide (8f)
Type:
Small organic molecule
Emp. Form.:
C40H36N8O5S
Mol. Mass.:
740.829
SMILES:
COc1ccc(Nc2nc(Nc3ccc(OC)cc3)nc(n2)-n2nc(cc2-c2ccc(OC)cc2)-c2ccc(NS(=O)(=O)c3ccc(C)cc3)cc2)cc1
Structure:
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