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Target
Protein mono-ADP-ribosyltransferase PARP3 [R100H]
Ligand
BDBM199181
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay
IC50
>1.00e+5±n/a nM
Citation
 Venkannagari, H; Verheugd, P; Koivunen, J; Haikarainen, T; Obaji, E; Ashok, Y; Narwal, M; Pihlajaniemi, T; Lüscher, B; Lehtiö, L Small-Molecule Chemical Probe Rescues Cells from Mono-ADP-Ribosyltransferase ARTD10/PARP10-Induced Apoptosis and Sensitizes Cancer Cells to DNA Damage. Cell Chem Biol 23:1251-1260 (2016) [PubMed]  Article 
Target
Name:
Protein mono-ADP-ribosyltransferase PARP3 [R100H]
Synonyms:
(ARTD3 or PARP3) | ADP-ribosyltransferase diphtheria toxin-like 3 | ADPRT3 | ADPRTL3 | Human diphtheria toxin-like ADP-ribosyltransferase (ARTD3 or PARP3) | PARP3 | PARP3_HUMAN | Poly [ADP-ribose] polymerase 3 | Poly [ADP-ribose] polymerase 3 (PARP-3) | Poly(ADP-ribose) polymerase-3 (ARTD3/PARP3)
Type:
PROTEIN
Mol. Mass.:
60071.85
Organism:
Homo sapiens (Human)
Description:
Q9Y6F1[R100H]
Residue:
533
Sequence:
MAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKRIIRVDPTCPLSSNPGTQVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNHWGRVGEVGQSKINHFTRLEDAKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPVRTVTKRVQPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEALKGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCPTLQHIWKVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPTQDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
  
Inhibitor
Name:
BDBM199181
Synonyms:
4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carboxamide (OUL35)
Type:
Small organic molecule
Emp. Form.:
C14H12N2O3
Mol. Mass.:
256.2567
SMILES:
NC(=O)c1ccc(Oc2ccc(cc2)C(N)=O)cc1
Structure:
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