Reaction Details Report a problem with these data
Target
Poly [ADP-ribose] polymerase tankyrase-2 [873-1161]
Ligand
BDBM199181
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay
IC50
>1.00e+5±n/a nM
Citation
 Venkannagari, H; Verheugd, P; Koivunen, J; Haikarainen, T; Obaji, E; Ashok, Y; Narwal, M; Pihlajaniemi, T; Lüscher, B; Lehtiö, L Small-Molecule Chemical Probe Rescues Cells from Mono-ADP-Ribosyltransferase ARTD10/PARP10-Induced Apoptosis and Sensitizes Cancer Cells to DNA Damage. Cell Chem Biol 23:1251-1260 (2016) [PubMed]  Article 
Target
Name:
Poly [ADP-ribose] polymerase tankyrase-2 [873-1161]
Synonyms:
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b) | PARP5B | TANK2 | TNKL | TNKS2 | TNKS2_HUMAN
Type:
n/a
Mol. Mass.:
32865.54
Organism:
Homo sapiens (Human)
Description:
Q9H2K2[873-1161]
Residue:
289
Sequence:
GVDFSITQFVRNLGLEHLMDIFEREQITLDVLVEMGHKELKEIGINAYGHRHKLIKGVERLISGQQGLNPYLTLNTSGSGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
  
Inhibitor
Name:
BDBM199181
Synonyms:
4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carboxamide (OUL35)
Type:
Small organic molecule
Emp. Form.:
C14H12N2O3
Mol. Mass.:
256.2567
SMILES:
NC(=O)c1ccc(Oc2ccc(cc2)C(N)=O)cc1
Structure:
Search PDB for entries with ligand similarity: