Reaction Details Report a problem with these data
Target
Protein mono-ADP-ribosyltransferase PARP15 [460-656,Y598L]
Ligand
BDBM199181
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay
IC50
295±0.0 nM
Citation
 Venkannagari, H; Verheugd, P; Koivunen, J; Haikarainen, T; Obaji, E; Ashok, Y; Narwal, M; Pihlajaniemi, T; Lüscher, B; Lehtiö, L Small-Molecule Chemical Probe Rescues Cells from Mono-ADP-Ribosyltransferase ARTD10/PARP10-Induced Apoptosis and Sensitizes Cancer Cells to DNA Damage. Cell Chem Biol 23:1251-1260 (2016) [PubMed]  Article 
Target
Name:
Protein mono-ADP-ribosyltransferase PARP15 [460-656,Y598L]
Synonyms:
BAL3 | Human diphtheria toxin-like ADP-ribosyltransferase (Y598L) (ARTD7 or PARP15 (Y598L)) | PAR15_HUMAN | PARP15
Type:
n/a
Mol. Mass.:
22452.58
Organism:
Homo sapiens (Human)
Description:
Q460N3[460-656,Y598L]
Residue:
197
Sequence:
MKKRDLSASLNFQSTFSMTTCNLPEHWTDMNHQLFCMVQLEPGQSEYNTIKDKFTRTCSSYAIEKIERIQNAFLWQSYQVKKRQMDIKNDHKNNERLLFHGTDADSVPYVNQHGFNRSCAGKNAVSYGKGTYFAVDASLSAKDTYSKPDSNGRKHMYVVRVLTGVFTKGRAGLVTPPPKNPHNPTDLFDSVTNNTRS
  
Inhibitor
Name:
BDBM199181
Synonyms:
4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carboxamide (OUL35)
Type:
Small organic molecule
Emp. Form.:
C14H12N2O3
Mol. Mass.:
256.2567
SMILES:
NC(=O)c1ccc(Oc2ccc(cc2)C(N)=O)cc1
Structure:
Search PDB for entries with ligand similarity: