Reaction Details Report a problem with these data
Target
Opioid growth factor receptor-like protein 1
Ligand
BDBM199357
Substrate
n/a
Meas. Tech.
Functional Assay
pH
7.4±n/a
Temperature
323.15±n/a K
EC50
2440.53±310.95 nM
Comments
extracted
Citation
 Kyle, DJ; Tafesse, L Buprenorphine analogs US Patent  US9221831 Publication Date 12/29/2015 
Target
Name:
Opioid growth factor receptor-like protein 1
Synonyms:
OGFRL1 | OGRL1_HUMAN | Opioid Receptor-Like Receptor (ORL-1) | Opioid growth factor receptor-like protein 1 (ORL-1) | Opioid growth factor receptor-like protein 1 (ORL1) | Opioid receptor-like (ORL-1) | Opioid receptor-like (ORL1) | Opioid receptor-like protein 1 (OGL1) | Opioid receptor-like receptor (ORL1)
Type:
Protein
Mol. Mass.:
51247.53
Organism:
Homo sapiens (Human)
Description:
Q5TC84
Residue:
451
Sequence:
MGNLLGGVSFREPTTVEDCDSTWQTDSEPEPEEPGPGGGSEGPGQESEQPAQPPEQAGGRPGASPAPDEDAEAAGAEQGGDSTEATAKPKRSFYAARDLYKYRHQYPNFKDIRYQNDLSNLRFYKNKIPFKPDGVYIEEVLSKWKGDYEKLEHNHTYIQWLFPLREQGLNFYAKELTTYEIEEFKKTKEAIRRFLLAYKMMLEFFGIKLTDKTGNVARAVNWQERFQHLNESQHNYLRITRILKSLGELGYESFKSPLVKFILHEALVENTIPNIKQSALEYFVYTIRDRRERRKLLRFAQKHYTPSENFIWGPPRKEQSEGSKAQKMSSPLASSHNSQTSMHKKAKDSKNSSSAVHLNSKTAEDKKVAPKEPVEETDRPSPEPSNEAAKPRNTEKDSNAENMNSQPEKTVTTPTEKKESVSPENNEEGGNDNQDNENPGNTNCHDVVLVQ
  
Inhibitor
Name:
BDBM199357
Synonyms:
US9221831, 22
Type:
Small organic molecule
Emp. Form.:
C27H31NO4
Mol. Mass.:
433.5393
SMILES:
CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccccc1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CCN1)c45 |r,TLB:8:7:27.26:4.3|
Structure:
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