Reaction Details Report a problem with these data
Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM50447777
Substrate
n/a
Meas. Tech.
In Vitro Assay: Intracellular Calcium Measurements
Temperature
310.15±n/a K
IC50
1342±n/a nM
Comments
extracted
Citation
 Aissaoui, H; Boss, C; Brotschi, C; Heidmann, B; Sifferlen, T; Williams, JT Lactam derivatives useful as orexin receptor antagonists US Patent  US9242970 Publication Date 1/26/2016 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM50447777
Synonyms:
CHEMBL3113537 | US9242970, 220
Type:
Small organic molecule
Emp. Form.:
C20H19F4NO3
Mol. Mass.:
397.3634
SMILES:
COc1cccc(F)c1C1CCCC(=O)N1Cc1ccc(OC(F)(F)F)cc1
Structure:
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