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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM203517
Substrate
n/a
Meas. Tech.
IMAP technology (Molecular Devices)
pH
7.2±n/a
Temperature
298.15±n/a K
IC50
654±n/a nM
Comments
extracted
Citation
 Seganish, WM; Brumfield, SN; Lim, J; Matasi, JJ; McElroy, WT; Tulshian, DB; Lavey, BJ; Altman, MD; Gibeau, CR; Lampe, JW; Methot, J; Zhu, L Aminopyrimidinones as interleukin receptor-associated kinase inhibitors US Patent  US9221809 Publication Date 12/29/2015 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM203517
Synonyms:
US9221809, 54
Type:
Small organic molecule
Emp. Form.:
C22H22N6O4S
Mol. Mass.:
466.513
SMILES:
OC[C@H]1C[C@@H](Nc2nc(Nc3ccncc3)[nH]c(=O)c2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O |r|
Structure:
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