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TargetMAP kinase ERK2
LigandBDBM204169
Substrate/Competitorn/a
Meas. Tech.ERK2 (20 pM) Kinase Assay
IC50 0.0121±n/a nM
Citation Bagdanoff, JTDing, YHan, WHuang, ZJiang, QJin, JXKou, XLee, PLindvall, MMin, ZPan, YPecchi, SPfister, KBPoon, DRauniyar, VWang, XMZhang, QZhou, JZhu, S Aminoheteroaryl benzamides as kinase inhibitors US Patent US9242996 Publication Date 1/26/2016
More Info.:Get all data from this article,  Assay Method
 
MAP kinase ERK2
Name:MAP kinase ERK2
Synonyms:ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | Mitogen activated kinase 1 (ERK-2) | Mitogen-Activated Protein Kinase 1 | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | p42-MAPK
Type:Ser/Thr Protein Kinase
Mol. Mass.:41392.76
Organism:Homo sapiens (human)
Description:Obtained from Calbiochem.
Residue:360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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  Blast E-value cutoff:
BDBM204169
n/a
NameBDBM204169
Synonyms:US9242996, 243
TypeSmall organic molecule
Emp. Form.C26H24F3N5O2
Mol. Mass.495.4963
SMILESCc1nn(C)cc1-c1cnc(N)c(c1)-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(CF)c2)c(F)c1 |r|
Structure
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