Reaction Details Report a problem with these data
Target
Alpha-enolase
Ligand
BDBM204924
Substrate
n/a
Meas. Tech.
Enolase Enzymatic Assays
pH
7.4±n/a
IC50
37.9±0.0 nM
Comments
extracted
Citation
 Leonard, PG; Satani, N; Maxwell, D; Lin, YH; Hammoudi, N; Peng, Z; Pisaneschi, F; Link, TM; Lee, GR; Sun, D; Prasad, BA; Di Francesco, ME; Czako, B; Asara, JM; Wang, YA; Bornmann, W; DePinho, RA; Muller, FL SF2312 is a natural phosphonate inhibitor of enolase. Nat Chem Biol 12:1053-1058 (2016) [PubMed]  Article 
Target
Name:
Alpha-enolase
Synonyms:
2-phospho-D-glycerate hydro-lyase | 4.2.1.11 | C-myc promoter-binding protein | ENO1 | ENO1L1 | ENOA_HUMAN | Enolase 1 | Enolase 1 (ENO1) | MBP-1 | MBPB1 | MPB-1 | MPB1 | NNE | Non-neural enolase | Phosphopyruvate hydratase | Plasminogen-binding protein
Type:
n/a
Mol. Mass.:
47171.43
Organism:
Homo sapiens (Human)
Description:
P06733
Residue:
434
Sequence:
MSILKIHAREIFDSRGNPTVEVDLFTSKGLFRAAVPSGASTGIYEALELRDNDKTRYMGKGVSKAVEHINKTIAPALVSKKLNVTEQEKIDKLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNSEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAANFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEGLELLKTAIGKAGYTDKVVIGMDVAASEFFRSGKYDLDFKSPDDPSRYISPDQLADLYKSFIKDYPVVSIEDPFDQDDWGAWQKFTASAGIQVVGDDLTVTNPKRIAKAVNEKSCNCLLLKVNQIGSVTESLQACKLAQANGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLLRIEEELGSKAKFAGRNFRNPLAK
  
Inhibitor
Name:
BDBM204924
Synonyms:
SF2312
Type:
Small organic molecule
Emp. Form.:
C4H8NO6P
Mol. Mass.:
197.0832
SMILES:
O[C@H]1C[C@@H](C(=O)N1O)P(O)(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: