Reaction Details Report a problem with these data
Target
Apoptosis regulator Bcl-2 [1-204]
Ligand
BDBM156393
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
pH
7.5±n/a
IC50
0.8±n/a nM
Comments
extracted
Citation
 Diebold, RB; Gero, TW; Grover, P; Huang, S; Ioannidis, S; Ogoe, CA; Saeh, JC Chemical compounds US Patent  US9248140 Publication Date 2/2/2016 
Target
Name:
Apoptosis regulator Bcl-2 [1-204]
Synonyms:
Apoptosis regulator Bcl-2 | BCL2 | BCL2_HUMAN
Type:
Protein
Mol. Mass.:
22461.03
Organism:
Homo sapiens (Human)
Description:
C-terminal 6XHIS tagged Bcl-2 (aa 1-204)
Residue:
204
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGP
  
Inhibitor
Name:
BDBM156393
Synonyms:
US9018381, 16 | US9248140, 16
Type:
Small organic molecule
Emp. Form.:
C45H48ClN5O7S2
Mol. Mass.:
870.475
SMILES:
O[C@H](C1CCN(CC1)c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(N[C@H](CCN2CCOCC2)CSc2ccccc2)c(c1)[N+]([O-])=O)c1ccccc1-c1ccc(Cl)cc1 |r|
Structure:
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