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Target
Casein kinase I isoform epsilon
Ligand
BDBM207002
Substrate
n/a
Meas. Tech.
In Vitro ATP-33P Casein Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
2±n/a nM
Comments
extracted
Citation
 Cote-Des-Combes, S; Froissant, J; Gibert, J; Marguet, F; Pacaud, C; Puech, F; Ravet, A 3,4-dihydropyrrolo[1,2-A]pyrazine-2,8(1H)-dicarboxamide derivatives, preparation thereof and therapeutic use thereof for diseases involving casein kinase 1 epsilon and/or casein kinase 1 delta US Patent  US9233965 Publication Date 1/12/2016 
Target
Name:
Casein kinase I isoform epsilon
Synonyms:
Axin-1/Casein kinase I epsilon | CKI-epsilon | CKIe | CSNK1E | Casein kinase 1 epsilon (CK1Ɛ) | Casein kinase I epsilon | Casein kinase I isoform epsilon (CK1 epsilon) | Casein kinase I isoform epsilon (CK1E) | Casein kinase I isoform epsilon (CK1epsilon) | KC1E_HUMAN
Type:
Protein
Mol. Mass.:
47340.25
Organism:
Homo sapiens (Human)
Description:
P49674
Residue:
416
Sequence:
MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARNPEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAGNTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
  
Inhibitor
Name:
BDBM207002
Synonyms:
US9233965, 85
Type:
Small organic molecule
Emp. Form.:
C22H23ClF4N4O3
Mol. Mass.:
502.89
SMILES:
NC(=O)c1c2CN(CCn2c(Cl)c1-c1cccc(F)c1)C(=O)NC1CCC(O)(CC1)C(F)(F)F |(5.19,2.57,;3.7,2.18,;2.61,3.26,;3.3,.69,;1.84,.21,;.51,.98,;-.83,.21,;-.83,-1.33,;.51,-2.1,;1.84,-1.33,;3.3,-1.8,;3.7,-3.29,;4.21,-.56,;5.75,-.56,;6.52,-1.89,;8.06,-1.89,;8.83,-.56,;8.06,.78,;8.83,2.11,;6.52,.78,;-2.16,.98,;-2.16,2.52,;-3.49,.21,;-4.83,.98,;-6.16,.21,;-7.5,.98,;-7.5,2.52,;-8.83,3.29,;-6.16,3.29,;-4.83,2.52,;-8.83,1.75,;-10.37,1.75,;-9.92,.66,;-8.43,.26,)|
Structure:
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