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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Ephrin type-A receptor 2 (EPHA2) | ||
| Ligand | BDBM209862 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinobeads Competition Assay | ||
| Kd | 265±0.0 nM | ||
| Citation |  Heinzlmeir, S; Kudlinzki, D; Sreeramulu, S; Klaeger, S; Gande, SL; Linhard, V; Wilhelm, M; Qiao, H; Helm, D; Ruprecht, B; Saxena, K; Médard, G; Schwalbe, H; Kuster, B Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs. ACS Chem Biol11:3400-3411 (2016) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Ephrin type-A receptor 2 (EPHA2) | |||
| Name: | Ephrin type-A receptor 2 (EPHA2) | ||
| Synonyms: | n/a | ||
| Type: | Protein | ||
| Mol. Mass.: | 34367.96 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | EPHA2 truncation (596-900 aa); 519U | ||
| Residue: | 305 | ||
| Sequence: |
| ||
| BDBM209862 | |||
| n/a | |||
| Name | BDBM209862 | ||
| Synonyms: | 4-(3-chloro-2-fluorophenoxy)-1-[[6-(1,3-thiazol-2-ylamino)pyridin-2-yl]methyl]cyclohexane-1-carboxylic acid | MK-5108 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H21ClFN3O3S | ||
| Mol. Mass. | 461.937 | ||
| SMILES | OC(=O)C1(Cc2cccc(Nc3nccs3)n2)CCC(CC1)Oc1cccc(Cl)c1F |(6.1,3.85,;7.64,3.85,;8.41,5.18,;8.41,2.52,;9.18,3.85,;10.72,3.85,;11.49,5.18,;13.03,5.18,;13.8,3.85,;13.03,2.52,;13.8,1.18,;15.35,1.18,;16.25,-.06,;17.71,.41,;17.71,1.95,;16.25,2.43,;11.49,2.52,;7.08,1.75,;7.08,.21,;8.41,-.56,;9.75,.21,;9.75,1.75,;8.41,-2.1,;7.08,-2.87,;7.08,-4.41,;5.75,-5.18,;4.41,-4.41,;4.41,-2.87,;3.08,-2.1,;5.75,-2.1,;5.75,-.56,)| | ||
| Structure | 
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