Target
Tyrosine-protein kinase ABL1 [64-515]
Ligand
BDBM213662
Substrate
n/a
Meas. Tech.
Radio ABL1 (64-515) Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
<0.1±n/a nM
Comments
extracted
Citation
 Furet, PGrotzfeld, RMJahnke, WJones, DBManley, PWMarzinzik, APelle, XFSalem, BSchoepfer, JSpieser, EA Compounds and compositions for inhibiting the activity of ABL1, ABL2 and BCR-ABL1 US Patent  US9278981 Publication Date 3/8/2016 
Target
Name:
Tyrosine-protein kinase ABL1 [64-515]
Synonyms:
ABL | ABL1 | ABL1_HUMAN | JTK7 | Tyrosine-protein kinase ABL1 | Tyrosine-protein kinase ABL1 (64-515) | Tyrosine-protein kinase ABL1 (ABL) | Tyrosine-protein kinase ABL1 (ABL1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51539.77
Organism:
Homo sapiens (Human)
Description:
aa 64-515
Residue:
452
Sequence:
NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGV
  
Inhibitor
Name:
BDBM213662
Synonyms:
US9278981, 254
Type:
Small organic molecule
Emp. Form.:
C22H16ClF2N7O2
Mol. Mass.:
483.858
SMILES:
FC(F)(Cl)Oc1ccc(NC(=O)c2cnc(N3Cc4cn[nH]c4C3)c(c2)-c2cncnc2)cc1
Structure:
Search PDB for entries with ligand similarity: