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Target
Isoform Tau-F of Microtubule-associated protein tau
Ligand
BDBM214726
Substrate
n/a
Meas. Tech.
Tau Protein Assay
pH
7.4±n/a
IC50
1.2e+2± 1e+1 nM
Comments
extracted
Citation
 Schafer, KN; Cisek, K; Huseby, CJ; Chang, E; Kuret, J Structural determinants of Tau aggregation inhibitor potency. J Biol Chem 288:32599-611 (2013) [PubMed]  Article 
Target
Name:
Isoform Tau-F of Microtubule-associated protein tau
Synonyms:
MAPT | MAPTL | MTBT1 | Microtubule-associated protein | Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R) | Microtubule-associated protein tau (TAU)(2N4R) | TAU | TAU_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45857.42
Organism:
Homo sapiens (Human)
Description:
P10636-8
Residue:
441
Sequence:
MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
  
Inhibitor
Name:
BDBM214726
Synonyms:
Cyanines, 9
Type:
Small organic molecule
Emp. Form.:
C42H38N4S4
Mol. Mass.:
727.037
SMILES:
C1CC[n+]2c(\C=C\C=C3/Sc4ccccc4N3CCCC[n+]3c(\C=C\C=C4/Sc5ccccc5N4C1)sc1ccccc31)sc1ccccc21 |c:7,27,t:5,25|
Structure:
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