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Target
Isoform Tau-F of Microtubule-associated protein tau
Ligand
BDBM214727
Substrate
n/a
Meas. Tech.
Tau Protein Assay
pH
7.4±n/a
IC50
1.28e+3± 3.2e+2 nM
Comments
extracted
Citation
 Schafer, KN; Cisek, K; Huseby, CJ; Chang, E; Kuret, J Structural determinants of Tau aggregation inhibitor potency. J Biol Chem 288:32599-611 (2013) [PubMed]  Article 
Target
Name:
Isoform Tau-F of Microtubule-associated protein tau
Synonyms:
MAPT | MAPTL | MTBT1 | Microtubule-associated protein | Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R) | Microtubule-associated protein tau (TAU)(2N4R) | TAU | TAU_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45857.42
Organism:
Homo sapiens (Human)
Description:
P10636-8
Residue:
441
Sequence:
MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
  
Inhibitor
Name:
BDBM214727
Synonyms:
Azure B (11)
Type:
Small organic molecule
Emp. Form.:
C15H16N3S
Mol. Mass.:
270.372
SMILES:
CNc1ccc2nc3ccc(cc3sc2c1)=[N+](C)C |(-6.26,1.98,;-4.92,1.21,;-3.59,1.98,;-3.59,3.52,;-2.25,4.29,;-.92,3.52,;.41,4.29,;1.75,3.52,;3.08,4.29,;4.41,3.52,;4.41,1.98,;3.08,1.21,;1.75,1.98,;.41,1.21,;-.92,1.98,;-2.25,1.21,;5.75,1.21,;7.08,1.98,;5.75,-.33,)|
Structure:
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