Target
Isoform Tau-F of Microtubule-associated protein tau
Ligand
BDBM214757
Substrate
n/a
Meas. Tech.
Tau Protein Assay
pH
7.4±n/a
IC50
2.56e+3±n/a nM
Comments
extracted
Citation
 Schafer, KNCisek, KHuseby, CJChang, EKuret, J Structural determinants of Tau aggregation inhibitor potency. J Biol Chem 288:32599-611 (2013) [PubMed]  Article 
Target
Name:
Isoform Tau-F of Microtubule-associated protein tau
Synonyms:
MAPT | MAPTL | MTBT1 | Microtubule-associated protein | Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R) | Microtubule-associated protein tau (TAU)(2N4R) | TAU | TAU_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45857.42
Organism:
Homo sapiens (Human)
Description:
P10636-8
Residue:
441
Sequence:
MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
  
Inhibitor
Name:
BDBM214757
Synonyms:
Rhodanines, 45A
Type:
Small organic molecule
Emp. Form.:
C18H14ClNO6
Mol. Mass.:
375.76
SMILES:
CCOC(=O)CN1C(=O)O\C(=C/c2ccc(o2)-c2cccc(Cl)c2)C1=O
Structure:
Search PDB for entries with ligand similarity: