Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM32188
Substrate
n/a
Meas. Tech.
HDAC Cell-Free Assays
pH
8±n/a
IC50
1.06e+5±n/a nM
Comments
extracted
Citation
 Cao, B; Li, J; Zhu, J; Shen, M; Han, K; Zhang, Z; Yu, Y; Wang, Y; Wu, D; Chen, S; Sun, A; Tang, X; Zhao, Y; Qiao, C; Hou, T; Mao, X The antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity. J Biol Chem 288:34181-9 (2013) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM32188
Synonyms:
CLIOQUINOL | Clioquinol (CQ) | TG2-36-2 | cid_2788
Type:
Small organic molecule
Emp. Form.:
C9H5ClINO
Mol. Mass.:
305.5
SMILES:
Oc1c(I)cc(Cl)c2cccnc12
Structure:
Search PDB for entries with ligand similarity: