Reaction Details Report a problem with these data
Target
Uridine 5'-monophosphate synthase
Ligand
BDBM214786
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8±n/a
Temperature
298.15±n/a K
Ki
80±36 nM
Comments
extracted
Citation
 Zhang, Y; Evans, GB; Clinch, K; Crump, DR; Harris, LD; Fröhlich, RF; Tyler, PC; Hazleton, KZ; Cassera, MB; Schramm, VL Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases. J Biol Chem 288:34746-54 (2013) [PubMed]  Article 
Target
Name:
Uridine 5'-monophosphate synthase
Synonyms:
Orotate phosphoribosyltransferase (HsOPRT) | Orotidine Monophosphate Decarboxylase (ODCase) | UMPS | UMPS_HUMAN
Type:
Enzyme
Mol. Mass.:
52224.99
Organism:
Homo sapiens (Human)
Description:
P11172
Residue:
480
Sequence:
MAVARAALGPLVTGLYDVQAFKFGDFVLKSGLSSPIYIDLRGIVSRPRLLSQVADILFQTAQNAGISFDTVCGVPYTALPLATVICSTNQIPMLIRRKETKDYGTKRLVEGTINPGETCLIIEDVVTSGSSVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAHGIRLHSVCTLSKMLEILEQQKKVDAETVGRVKRFIQENVFVAANHNGSPLSIKEAPKELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLGV
  
Inhibitor
Name:
BDBM214786
Synonyms:
OPRT inhibitor, 9
Type:
Small organic molecule
Emp. Form.:
C11H17BrN3O5
Mol. Mass.:
351.173
SMILES:
OC[C@@H]1C(O)C(O)C[NH+]1CCn1cc(Br)c(=O)[nH]c1=O |r|
Structure:
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