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TargetMDM2 and p53
LigandBDBM215167
Substrate/Competitorn/a
Meas. Tech.Homogenous Time-Resolved Fluorescence Assay (HTRF1 Assay)
pH7.4±n/a
Temperature298.15±n/a K
IC50 650±n/a nM
Commentsextracted
Citation Bartberger, MDGonzalez Buenrostro, ABeck, HPChen, XConnors, RVDeignan, JDuquette, JAEksterowicz, JFisher, BFox, BMFu, JFu, ZGonzalez Lopez De Turiso, FGribble, MWGustin, DJHeath, JAHuang, XJiao, XJohnson, MGKayser, FKopecky, DJLai, SLi, YLi, ZLiu, JLow, JDLucas, BSMa, ZMcGee, LRMcIntosh, JMcMinn, DLMedina, JCMihalic, JTOlson, SHRew, YRoveto, PMSun, DWang, XWang, YYan, XYu, MZhu, J Piperidinone derivatives as MDM2 inhibitors for the treatment of cancer US Patent US9296736 Publication Date 3/29/2016
More Info.:Get all data from this article,  Assay Method
 
MDM2 and p53
Name:MDM2 and p53
Synonyms:n/a
Type:Enzyme
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:E3 ubiquitin-protein ligase Mdm2 (aa 1-188)
Synonyms:n/a
Type:n/a
Mol. Mass.:21319.18
Organism:Homo sapiens (Human)
Description:n/a
Residue:188
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDS
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Component 2
Name:Tumor suppressor p53
Synonyms:n/a
Type:Enzyme
Mol. Mass.:8975.74
Organism:Homo sapiens (Human)
Description:Residues 1-83
Residue:83
Sequence:
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP
DEAPRMPEAAPPVAPAPAAPTPA
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BDBM215167
n/a
NameBDBM215167
Synonyms:US9296736, 118 | US9593129, Example 118
TypeSmall organic molecule
Emp. Form.C21H23Cl2NO4S
Mol. Mass.456.383
SMILESCC(C)N1[C@@H]([C@H](C[C@@H](CC(O)=O)S1(=O)=O)c1cccc(Cl)c1)c1ccc(Cl)cc1 |r|
Structure
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