Target
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188]
Ligand
BDBM215394
Substrate
n/a
Meas. Tech.
Homogenous Time-Resolved Fluorescence Assay (HTRF2 Assay)
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
0.1±n/a nM
Comments
extracted
Citation
Target
Name:
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188]
Synonyms:
MDM2 and p53 | mdm2
Type:
Enzyme
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
E3 ubiquitin-protein ligase Mdm2 [1-188]
Synonyms:
E3 ubiquitin-protein ligase Mdm2 (aa 1-188) | MDM2 | MDM2_HUMAN
Type:
n/a
Mol. Mass.:
21319.18
Organism:
Homo sapiens (Human)
Description:
Q00987[1-188]
Residue:
188
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDS
  
Component 2
Name:
Cellular tumor antigen p53 [1-83]
Synonyms:
P53 | P53_HUMAN | TP53 | Tumor suppressor p53
Type:
Enzyme
Mol. Mass.:
8975.74
Organism:
Homo sapiens (Human)
Description:
Residues 1-83
Residue:
83
Sequence:
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPA
  
Inhibitor
Name:
BDBM215394
Synonyms:
US9296736, 375 | US9593129, Example 375
Type:
Small organic molecule
Emp. Form.:
C29H36Cl2N2O5S
Mol. Mass.:
595.578
SMILES:
CC(C)(C)NS(=O)(=O)C[C@H](C1CC1)N1C([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: