Reaction Details Report a problem with these data
Target
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta
Ligand
BDBM217352
Substrate
n/a
Meas. Tech.
SelectScreen Biochemical Kinase Assay
IC50
>10000±0.0 nM
Citation
 Shugg, RP; Thomson, A; Tanabe, N; Kashishian, A; Steiner, BH; Puri, KD; Pereverzev, A; Lannutti, BJ; Jirik, FR; Dixon, SJ; Sims, SM Effects of isoform-selective phosphatidylinositol 3-kinase inhibitors on osteoclasts: actions on cytoskeletal organization, survival, and resorption. J Biol Chem 288:35346-57 (2013) [PubMed]  Article 
Target
Name:
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta
Synonyms:
PI51B_MOUSE | Phosphatidylinositol-4-phosphate 5-kinase beta (PIP5Kβ) | Pip5k1b
Type:
Enzyme
Mol. Mass.:
60805.07
Organism:
Mus musculus (Mouse)
Description:
P70181
Residue:
539
Sequence:
MSSTAENGDAVPGKQNEEKTYKKTASSAIKGAIQLGIGYTVGNLTSKPERDVLMQDFYVVESVFLPSEGSNLTPAHHYPDFRFKTYAPLAFRYFRELFGIKPDDYLYSICSEPLIELSNPGASGSLFFLTSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCMQSGGINIRIVVMNNVLPRAMRMHLTYDLKGSTYKRRASRKEREKPNPTFKDLDFLQDMHEGLYFDTETYNALMKTLQRDCRVLESFKIMDYSLLLGIHILDHSLKDKEEEPLQNVPDAKRPGMQKVLYSTAMESIQGPGKSADGIIAENPDTMGGIPAKSHKGEKLLLFMGIIDILQSYRLMKKLEHSWKALVYDGDTVSVHRPSFYADRFLKFMNSRVFKKIQALKASPSKKRCNSIAALKATSQEIVSSISQEWKDEKRDLLTEGQSFSSLDEEALGSRHRPDLVPSTPSLFEAASLATTISSSSLYVGEHYPHDRTTLYSNSKGLPSSSTFTLEEGTIYLTAEPNTLDLQDDASVLDVYL
  
Inhibitor
Name:
BDBM217352
Synonyms:
GS-9820
Type:
Small organic molecule
Emp. Form.:
C21H16FN7O
Mol. Mass.:
401.3964
SMILES:
C[C@H](Nc1ncnc2[nH]cnc12)c1nc2ccc(F)cc2c(=O)n1-c1ccccc1 |r|
Structure:
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