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Target
Trans-sialidase [3-643,Y342H]
Ligand
BDBM50048093
Substrate
BDBM217358
Meas. Tech.
Diffusion Ordered Spectroscopy (DOSY)
Temperature
284.15±n/a K
Kd
5.2e+4± 2e+3 nM
Comments
extracted
Citation
 Oliveira, IA; Gonçalves, AS; Neves, JL; von Itzstein, M; Todeschini, AR Evidence of ternary complex formation in Trypanosoma cruzi trans-sialidase catalysis. J Biol Chem 289:423-36 (2014) [PubMed]  Article 
Target
Name:
Trans-sialidase [3-643,Y342H]
Synonyms:
trans-Sialidase (TS Y342H)
Type:
Enzyme
Mol. Mass.:
70283.70
Organism:
Trypanosoma cruzi
Description:
T. cruzi TS Y342H mutant
Residue:
641
Sequence:
APGSSRVELFKRKNSTVPFEDKAGKVTERVVHSFRLPALVNVDGVMVAIADARYDTSNDNSLIDTVAKYSVDDGETWETQIAIKNSRVSSVSRVVDPTVIVKGNKLYVLVGSYYSSRSYWSSHGDARDWDILLAVGEVTKSIAGGKITASIKWGSPVSLKKFFPAEMEGMHTNQFLGGAGVAIVASNGNLVYPVQVTNKRKQVFSKIFYSEDDGKTWKFGKGRSDFGCSEPVALEWEGKLIINTRVDWKRRLVYESSDMGNTWVEAVGTLSRVWGPSPKSDHPGSQSSFTAVTIEGMRVMLFTHPLNFKGRWLRDRLNLWLTDNQRIYNVGQVSIGDENSAHSSVLYKDDKLYCLHEINTDEVYSLVFARLVGELRIIKSVLRSWKNWDSHLSSICTPADPAASSSESGCGPAVTTVGLVGFLSGNASQNVWEDAYRCVNASTANAERVRNGLKFAGVGGGALWPVSQQGQNQRYRFANHAFTLVASVTIHEAPRAASPLLGASLDSSGGKKLLGLSYDEKHQWQPIYGSTPVTPTGSWETGKRYHVVLTVANKIGSVYIDGELLEGSGQTVVPDGRTPDISHFYVGGYGRSDMPTISHVTVNNVLLYNRQLNTEEIRTLFLSQDLIGTEAHMDSSSDTSA
  
Inhibitor
Name:
BDBM50048093
Synonyms:
CHEBI:610092 | CHEMBL503075 | Lactoside | Methyl Beta-D-Lactoside
Type:
Small organic molecule
Emp. Form.:
C13H24O11
Mol. Mass.:
356.3231
SMILES:
CO[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O |r|
Structure:
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Substrate
Name:
BDBM217358
Synonyms:
α2,3'-sialyllactose | 3-SL
Type:
Small organic molecule
Emp. Form.:
C23H39NO19
Mol. Mass.:
633.5511
SMILES:
CC(=O)NC1C(O)CC(OC2C(O)C(CO)OC(OC3C(CO)OC(O)C(O)C3O)C2O)(OC1[C@H](O)[C@H](O)CO)C(O)=O |r|
Structure:
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