Reaction Details Report a problem with these data
Target
S-methyl-5'-thioinosine phosphorylase
Ligand
BDBM50247149
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.4±n/a
Temperature
298.15±n/a K
Ki
0.076±n/a nM
Comments
extracted
Citation
 Schramm, VL; Clinch, K; Tyler, PC; Evans, GB; Furneaux, RH Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase US Patent  US9290501 Publication Date 3/22/2016 
Target
Name:
S-methyl-5'-thioinosine phosphorylase
Synonyms:
MTIP_PSEAE | S-methyl-5'-thioinosine phosphorylase (MTIP)
Type:
Enzyme
Mol. Mass.:
26266.70
Organism:
Pseudomonas aeruginosa
Description:
Q9HZK1
Residue:
245
Sequence:
MSVYAIIGGTGLTQLEGLTLSESLPIETPYGAPSAPLQRGRYAGREVLFLARHGHPHRFPPHQVNYRANLWALKQAGAEAVIAVNAVGGIHAAMGTGHLCVPHQLIDYTSGREHTYFAGDIEHVTHIDFSHPYDEPLRQRLIEALRALGLAHSSHGVYACTQGPRLETVAEIARLERDGNDIVGMTGMPEAALARELDLPYACLALVVNPAAGKSAGIITMAEIEQALHDGIGKVREVLARVLAG
  
Inhibitor
Name:
BDBM50247149
Synonyms:
5'-Methylthio-ImmH | CHEMBL473929 | US9290501, (A)
Type:
Small organic molecule
Emp. Form.:
C12H16N4O3S
Mol. Mass.:
296.345
SMILES:
CSC[C@H]1N[C@H]([C@H](O)[C@@H]1O)c1c[nH]c2c1nc[nH]c2=O |r|
Structure:
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