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Target
Pancreatic alpha-amylase
Ligand
BDBM223316
Substrate
n/a
Meas. Tech.
Inhibition Kinetics Assay
pH
7±n/a
Ki
7.0±3.5 nM
Comments
extracted
Citation
 Jongkees, SA; Caner, S; Tysoe, C; Brayer, GD; Withers, SG; Suga, H Rapid Discovery of Potent and Selective Glycosidase-Inhibiting De Novo Peptides. Cell Chem Biol 24:381-390 (2017) [PubMed]  Article 
Target
Name:
Pancreatic alpha-amylase
Synonyms:
1,4-alpha-D-glucan glucanohydrolase | AMY2A | AMYP_HUMAN | PA | Pancreatic α-amylase (HPA) | Pancreatic alpha-amylase | Pancreatic alpha-amylase (HPA)
Type:
Protein
Mol. Mass.:
57709.71
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
511
Sequence:
MKFFLLLFTIGFCWAQYSPNTQQGRTSIVHLFEWRWVDIALECERYLAPKGFGGVQVSPPNENVAIYNPFRPWWERYQPVSYKLCTRSGNEDEFRNMVTRCNNVGVRIYVDAVINHMCGNAVSAGTSSTCGSYFNPGSRDFPAVPYSGWDFNDGKCKTGSGDIENYNDATQVRDCRLTGLLDLALEKDYVRSKIAEYMNHLIDIGVAGFRLDASKHMWPGDIKAILDKLHNLNSNWFPAGSKPFIYQEVIDLGGEPIKSSDYFGNGRVTEFKYGAKLGTVIRKWNGEKMSYLKNWGEGWGFVPSDRALVFVDNHDNQRGHGAGGASILTFWDARLYKMAVGFMLAHPYGFTRVMSSYRWPRQFQNGNDVNDWVGPPNNNGVIKEVTINPDTTCGNDWVCEHRWRQIRNMVIFRNVVDGQPFTNWYDNGSNQVAFGRGNRGFIVFNNDDWSFSLTLQTGLPAGTYCDVISGDKINGNCTGIKIYVSDDGKAHFSISNSAEDPFIAIHAESKL
  
Inhibitor
Name:
BDBM223316
Synonyms:
YPYSCWVRH | piHA-Dm
Type:
Small organic molecule
Emp. Form.:
C59H76N16O13S2
Mol. Mass.:
1281.464
SMILES:
CC(C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CS)N1SCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CO)C1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O |r|
Structure:
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