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TargetCarbonic anhydrase 2
LigandBDBM224001
Substrate/Competitorn/a
Meas. Tech.Fluorescence-Based CA II Binding Assay
pH7±0
Temperature298.15±0 K
IC50 3.10e+3± 27 nM
Citation Teruya, KRankin, GMChrysanthopoulos, PKTonissen, KFPoulsen, SA Characterisation of Photoaffinity-Based Chemical Probes by Fluorescence Imaging and Native-State Mass Spectrometry. Chembiochem18:739-754 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Carbonic anhydrase 2
Name:Carbonic anhydrases; II & IX
Synonyms:CA-II | CA2 | CAC | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:Enzyme
Mol. Mass.:29250.71
Organism:Homo sapiens (Human)
Description:P00918
Residue:260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM224001
NameBDBM224001
Synonyms:N-[(1S)-2-[1-(4-Benzoylphenyl)-1H-1,2,3-triazol-4-yl]-1-{[(4-sulfamoylphenyl)methyl]carbamoyl}ethyl]-4,7,10,13,16-pentaoxanonadec-18-ynamide (8)
TypeSmall organic molecule
Emp. Form.C39H46N6O10S
Mol. Mass.790.882
SMILESNS(=O)(=O)c1ccc(CNC(=O)[C@H](Cc2cn(nn2)-c2ccc(cc2)C(=O)c2ccccc2)NC(=O)CCOCCOCCOCCOCCOCC#C)cc1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a