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Target
STAM-binding protein
Ligand
BDBM224012
Substrate
n/a
Meas. Tech.
In Vitro AMSH Activity Assay
IC50
4.5e+3±n/a nM
Citation
 Li, J; Yakushi, T; Parlati, F; Mackinnon, AL; Perez, C; Ma, Y; Carter, KP; Colayco, S; Magnuson, G; Brown, B; Nguyen, K; Vasile, S; Suyama, E; Smith, LH; Sergienko, E; Pinkerton, AB; Chung, TDY; Palmer, AE; Pass, I; Hess, S; Cohen, SM; Deshaies, RJ Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nat Chem Biol 13:486-493 (2017) [PubMed]  Article 
Target
Name:
STAM-binding protein
Synonyms:
AMSH | STABP_HUMAN | STAM-binding protein (AMSH) | STAMBP
Type:
Protein
Mol. Mass.:
48073.82
Organism:
Homo sapiens (Human)
Description:
O95630
Residue:
424
Sequence:
MSDHGDVSLPPEDRVRALSQLGSAVEVNEDIPPRRYFRSGVEIIRMASIYSEEGNIEHAFILYNKYITLFIEKLPKHRDYKSAVIPEKKDTVKKLKEIAFPKAEELKAELLKRYTKEYTEYNEEKKKEAEELARNMAIQQELEKEKQRVAQQKQQQLEQEQFHAFEEMIRNQELEKERLKIVQEFGKVDPGLGGPLVPDLEKPSLDVFPTLTVSSIQPSDCHTTVRPAKPPVVDRSLKPGALSNSESIPTIDGLRHVVVPGRLCPQFLQLASANTARGVETCGILCGKLMRNEFTITHVLIPKQSAGSDYCNTENEEELFLIQDQQGLITLGWIHTHPTQTAFLSSVDLHTHCSYQMMLPESVAIVCSPKFQETGFFKLTDHGLEEISSCRQKGFHPHSKDPPLFCSCSHVTVVDRAVTITDLR
  
Inhibitor
Name:
BDBM224012
Synonyms:
Capzimin | US10005735, Compound 12
Type:
Small organic molecule
Emp. Form.:
C15H13N3OS2
Mol. Mass.:
315.413
SMILES:
Sc1cccc2cc(cnc12)C(=O)NCCc1nccs1
Structure:
Search PDB for entries with ligand similarity: