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Target
Ribosomal protein S6 kinase beta-1
Ligand
BDBM224551
Substrate
n/a
Meas. Tech.
Enzyme Assay
pH
7.5±n/a
IC50
560±n/a nM
Comments
extracted
Citation
 Lan, R; Huck, BR; Chen, X; Deselm, LC; Qiu, H; Xiao, Y; Neagu, C; Mochalkin, I; Johnson, TL Aminopyrimidine derivatives for use as modulators of kinase activity US Patent  US9321760 Publication Date 4/26/2016 
Target
Name:
Ribosomal protein S6 kinase beta-1
Synonyms:
70 kDa ribosomal protein S6 kinase 1 | 70 kDa ribosomal protein S6 kinase 1 (P70s6k) | 70 kDa ribosomal protein kinase (p70S6K) | KS6B1_HUMAN | Protein kinase 70S6K (T412E) | RAC-alpha serine/threonine-protein kinase/Ribosomal protein S6 kinase beta-1 | RPS6KB1 | Ribosomal protein S6 kinase (P70S6K) | Ribosomal protein S6 kinase I | S6K1 | STK14A | p70 S6 ribosomal protein kinase 1 | p70S6K1
Type:
Enzyme
Mol. Mass.:
59139.89
Organism:
Homo sapiens (Human)
Description:
His-tagged S6K1.
Residue:
525
Sequence:
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSGIEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
  
Inhibitor
Name:
BDBM224551
Synonyms:
US10080750, Compound 234 | US9321760, 234 | US9662330, Compound 234
Type:
Small organic molecule
Emp. Form.:
C19H24Cl2N6O2
Mol. Mass.:
439.339
SMILES:
COC[C@H](NC(=O)C1(N)CCN(CC1)c1ncnc(N)c1Cl)c1ccc(Cl)cc1 |r|
Structure:
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