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Target
RNA polymerase sigma factor SigB
Ligand
BDBM226118
Substrate
n/a
Meas. Tech.
Biolayer Interferometry (BLI) Assay
Kd
51±6.5 nM
Citation
 Vishwanath, S; Banerjee, S; Jamithireddy, AK; Srinivasan, N; Gopal, B; Chatterjee, J Design, Synthesis, and Experimental Validation of Peptide Ligands Targeting Mycobacterium tuberculosis s Factors. Biochemistry 56:2209-2218 (2017) [PubMed]  Article 
Target
Name:
RNA polymerase sigma factor SigB
Synonyms:
RNA polymerase sigma factor SigB (σB) | RNA polymerase sigma factor SigB (ϿB) | SIGB_MYCTU | mysB | sigB
Type:
Protein
Mol. Mass.:
36343.42
Organism:
Mycobacterium tuberculosis
Description:
P9WGI5
Residue:
323
Sequence:
MADAPTRATTSRVDSDLDAQSPAADLVRVYLNGIGKTALLNAAGEVELAKRIEAGLYAEHLLETRKRLGENRKRDLAAVVRDGEAARRHLLEANLRLVVSLAKRYTGRGMPLLDLIQEGNLGLIRAMEKFDYTKGFKFSTYATWWIRQAITRGMADQSRTIRLPVHLVEQVNKLARIKREMHQHLGREATDEELAAESGIPIDKINDLLEHSRDPVSLDMPVGSEEEAPLGDFIEDAEAMSAENAVIAELLHTDIRSVLATLDEREHQVIRLRFGLDDGQPRTLDQIGKLFGLSRERVRQIERDVMSKLRHGERADRLRSYAS
  
Inhibitor
Name:
BDBM226118
Synonyms:
ELTPEERMLRLIFGRK | MT4
Type:
Small organic molecule
Emp. Form.:
C88H150N26O24S
Mol. Mass.:
1988.357
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCC(O)=O)[C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(O)=O |r|
Structure:
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