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TargetBromodomain protein 4 bromodomain 1 (BRD4 BD1 Y139F)
LigandBDBM50365262
Substrate/Competitorn/a
Meas. Tech.Thermal Shift Assay (TSA)
Kd 1.0±0.0 nM
Citation Jung, MPhilpott, MMüller, SSchulze, JBadock, VEberspächer, UMoosmayer, DBader, BSchmees, NFernández-Montalván, AHaendler, B Affinity map of bromodomain protein 4 (BRD4) interactions with the histone H4 tail and the small molecule inhibitor JQ1. J Biol Chem289:9304-19 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Bromodomain protein 4 bromodomain 1 (BRD4 BD1 Y139F)
Name:Bromodomain protein 4 bromodomain 1 (BRD4 BD1 Y139F)
Synonyms:n/a
Type:Protein
Mol. Mass.:14594.28
Organism:Homo sapiens (Human)
Description:Human BRD4 BD1 (44-166 aa) Y139F mutant
Residue:123
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKT
PMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIFNKPGDDIVLMAEALEKLFLQKINE
LPT
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BDBM50365262
n/a
NameBDBM50365262
Synonyms: (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US9320741, (S)-JQ1 | US9695172, JQ1
TypeSmall organic molecule
Emp. Form.C23H25ClN4O2S
Mol. Mass.456.988
SMILESCc1nnc2[C@H](CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |r,c:14|
Structure
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