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Target
Bone morphogenetic protein receptor type-1B
Ligand
BDBM111123
Substrate
n/a
Meas. Tech.
ALK1-6 enzymatic assays
pH
7.5±n/a
IC50
213±n/a nM
Comments
extracted
Citation
 Alimardanov, A; Cuny, GD; Grewal, GS; Lee, A; McKew, JC; Mohedas, AH; Shen, M; Xu, X; Yu, PB BMP inhibitors and methods of use thereof US Patent  US9682983 Publication Date 6/20/2017 
Target
Name:
Bone morphogenetic protein receptor type-1B
Synonyms:
ALK-6 | ALK6 | BMPR1B | BMR1B_HUMAN | Bone morphogenetic protein receptor type-1B (BMPR1B)
Type:
Enzyme
Mol. Mass.:
56939.41
Organism:
Homo sapiens (Human)
Description:
O00238
Residue:
502
Sequence:
MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEEDDSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVDGPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIKL
  
Inhibitor
Name:
BDBM111123
Synonyms:
US10017516, Compound 2 | US9682983, 2
Type:
Small organic molecule
Emp. Form.:
C27H26N6
Mol. Mass.:
434.5355
SMILES:
C[C@H]1CNC[C@@H](C)N1c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 |r|
Structure:
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