Target
Bone morphogenetic protein receptor type-1A
Ligand
BDBM161920
Substrate
n/a
Meas. Tech.
ALK1-6 enzymatic assays
pH
7.5±n/a
IC50
336±n/a nM
Comments
extracted
Citation
 Alimardanov, ACuny, GDGrewal, GSLee, AMcKew, JCMohedas, AHShen, MXu, XYu, PB BMP inhibitors and methods of use thereof US Patent  US9682983 Publication Date 6/20/2017 
Target
Name:
Bone morphogenetic protein receptor type-1A
Synonyms:
ACVRLK3 | ALK3 | Activin receptor-like kinase 3 (ALK-3) | BMPR1A | BMR1A_HUMAN
Type:
Enzyme
Mol. Mass.:
60204.46
Organism:
Homo sapiens (Human)
Description:
P36894
Residue:
532
Sequence:
MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYCKSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI
  
Inhibitor
Name:
BDBM161920
Synonyms:
US10017516, Compound 53 | US9682983, 52 | US9682983, 53
Type:
Small organic molecule
Emp. Form.:
C27H26N6
Mol. Mass.:
434.5355
SMILES:
C[C@H]1CNC[C@@H](C)N1c1ccc(cc1)-c1cnc2c(cnn2c1)-c1cccc2ncccc12 |r|
Structure:
Search PDB for entries with ligand similarity: