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Target
Tyrosine-protein kinase JAK3 [781-1124]
Ligand
BDBM228768
Substrate
n/a
Meas. Tech.
Enzymatic Assay
Temperature
298.15±n/a K
IC50
0.55±0.55 nM
Comments
extracted
Citation
 Su, W; Deng, W; Li, J; Ji, J Pyrrolopyrimidine compounds and uses thereof US Patent  US9346810 Publication Date 5/24/2016 
Target
Name:
Tyrosine-protein kinase JAK3 [781-1124]
Synonyms:
JAK3 | JAK3 (aa 781-1124) | JAK3_HUMAN | Janus kinase 3 (JAK3) | Tyrosine-protein kinase JAK3 | Tyrosine-protein kinase JAK3 (781-1124) | Tyrosine-protein kinase JAK3 (aa 781-1124)
Type:
n/a
Mol. Mass.:
38772.27
Organism:
Homo sapiens (Human)
Description:
P52333[781-1124]
Residue:
344
Sequence:
ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
  
Inhibitor
Name:
BDBM228768
Synonyms:
US10369153, Compound 17 | US9346810, 17
Type:
Small Organic Molecule
Emp. Form.:
C19H19N7O
Mol. Mass.:
361.4005
SMILES:
CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)C(=O)Nc1ccc(cc1)C#N
Structure:
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