Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase JAK3 [781-1124]
Ligand
BDBM228687
Substrate
n/a
Meas. Tech.
Enzymatic Assay
Temperature
298.15±n/a K
IC50
0.55±0.55 nM
Comments
extracted
Citation
 Su, W; Deng, W; Li, J; Ji, J Pyrrolopyrimidine compounds and uses thereof US Patent  US9346810 Publication Date 5/24/2016 
Target
Name:
Tyrosine-protein kinase JAK3 [781-1124]
Synonyms:
JAK3 | JAK3 (aa 781-1124) | JAK3_HUMAN | Janus kinase 3 (JAK3) | Tyrosine-protein kinase JAK3 | Tyrosine-protein kinase JAK3 (781-1124) | Tyrosine-protein kinase JAK3 (aa 781-1124)
Type:
n/a
Mol. Mass.:
38772.27
Organism:
Homo sapiens (Human)
Description:
P52333[781-1124]
Residue:
344
Sequence:
ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
  
Inhibitor
Name:
BDBM228687
Synonyms:
US10369153, Compound 202 | US9346810, 202
Type:
Small Organic Molecule
Emp. Form.:
C26H27FN6O2
Mol. Mass.:
474.53
SMILES:
CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cc1F)C(=O)NC[C@H](O)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: