Reaction Details Report a problem with these data
Target
NAD-dependent protein deacylase sirtuin-6
Ligand
BDBM228814
Substrate
n/a
Meas. Tech.
Fluorimetric Assay
IC50
4.169e+5± 1.504e+5 nM
Citation
 Bolívar, BE; Welch, JT Studies of the Binding of Modest Modulators of the Human Enzyme, Sirtuin 6, by STD NMR. Chembiochem 18:931-940 (2017) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacylase sirtuin-6
Synonyms:
NAD-dependent protein deacetylase sirtuin-6 | NAD-dependent protein deacetylase sirtuin-6 (SIRT6) | Regulatory protein SIR2 homolog 6 | SIR2-like protein 6 | SIR2L6 | SIR6_HUMAN | SIRT6 | Sirtuin-6 (SIRT6)
Type:
Protein
Mol. Mass.:
39133.03
Organism:
Homo sapiens (Human)
Description:
Q8N6T7
Residue:
355
Sequence:
MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAKAVPS
  
Inhibitor
Name:
BDBM228814
Synonyms:
PZA | Pyrazinamide | Tisamid | pyrazinecarboxamide
Type:
Small organic molecule
Emp. Form.:
C5H5N3O
Mol. Mass.:
123.1127
SMILES:
NC(=O)c1cnccn1
Structure:
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