Reaction Details
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Tyrosine-protein kinase ABL1 [131-238]
Ligand
BDBM231648
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
pH
7.25±n/a
Kd
3.27e+3± 7.4e+2 nM
Comments
extracted
Citation
Gifford, SM; Liu, W; Mader, CC; Halo, TL; Machida, K; Boggon, TJ; Koleske, AJ Two amino acid residues confer different binding affinities of Abelson family kinase SRC homology 2 domains for phosphorylated cortactin. J Biol Chem 289:19704-13 (2014) [PubMed] Article More Info.:
Target
Name:
Tyrosine-protein kinase ABL1 [131-238]
Synonyms:
ABL | ABL1 | ABL1_HUMAN | Abelson tyrosine-kinase 1 SH2 domain (ABL SH2) | JTK7
Type:
Protein
Mol. Mass.:
12162.87
Organism:
Homo sapiens (Human)
Description:
Truncated human ABL (131-238 aa)
Residue:
108
Sequence:
PVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEME
Inhibitor
Name:
BDBM231648
Synonyms:
SEPVpYETTE | pY466
Type:
Small organic molecule
Emp. Form.:
C45H68N9O23P
Mol. Mass.:
1134.0417
SMILES:
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(O)=O |r|
Structure:
