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Target
Voltage-dependent calcium channel gamma-2 subunit
Ligand
BDBM292036
Substrate
n/a
Meas. Tech.
Biological Assays Calcium Flux Assay
pH
7.4±n/a
IC50
15.8±n/a nM
Comments
extracted
Citation
 Ameriks, MK; Laforteza, BN; Savall, BM; Wade, WS; Meyer, ST; Gyuris, M 3-aryl-2H-pyrazolo[4,3-b]pyridine compounds and their use as AMPA receptor modulators US Patent  US10100045 Publication Date 10/16/2018 
Target
Name:
Voltage-dependent calcium channel gamma-2 subunit
Synonyms:
CACNG2 | CCG2_HUMAN | Neuronal voltage-gated calcium channel gamma-2 subunit | TARP gamma-2 | Transmembrane AMPAR regulatory protein gamma-2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35977.54
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
323
Sequence:
MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEVMTHSGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGLCIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSFYFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQASAITRIPSYRYRYQRRSRSSSRSTEPSHSRDASPVGIKGFNTLPSTEISMYTLSRDPLKAATTPTATYNSDRDNSFLQVHNCIQKENKDSLHSNTANRRTTPV
  
Inhibitor
Name:
BDBM292036
Synonyms:
5-(2-Cyclopentyl-5-(trifluoromethyl)-2H-pyrazolo[4,3-b]pyridin-3-yl)-1,3-dihydro- | US10100045, Example 7
Type:
Small organic molecule
Emp. Form.:
C19H16F3N5O
Mol. Mass.:
387.3584
SMILES:
FC(F)(F)c1ccc2nn(C3CCCC3)c(-c3ccc4[nH]c(=O)[nH]c4c3)c2n1
Structure:
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