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Target
Voltage-dependent calcium channel gamma-2 subunit
Ligand
BDBM292050
Substrate
n/a
Meas. Tech.
Biological Assays Calcium Flux Assay
pH
7.4±n/a
IC50
0.398±n/a nM
Comments
extracted
Citation
 Ameriks, MK; Laforteza, BN; Savall, BM; Wade, WS; Meyer, ST; Gyuris, M 3-aryl-2H-pyrazolo[4,3-b]pyridine compounds and their use as AMPA receptor modulators US Patent  US10100045 Publication Date 10/16/2018 
Target
Name:
Voltage-dependent calcium channel gamma-2 subunit
Synonyms:
CACNG2 | CCG2_HUMAN | Neuronal voltage-gated calcium channel gamma-2 subunit | TARP gamma-2 | Transmembrane AMPAR regulatory protein gamma-2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35977.54
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
323
Sequence:
MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEVMTHSGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGLCIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSFYFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQASAITRIPSYRYRYQRRSRSSSRSTEPSHSRDASPVGIKGFNTLPSTEISMYTLSRDPLKAATTPTATYNSDRDNSFLQVHNCIQKENKDSLHSNTANRRTTPV
  
Inhibitor
Name:
BDBM292050
Synonyms:
5-(2-Isopropyl-5-(trifluoromethyl)-2H-pyrazolo[4,3-b]pyridin-3-yl)-7-methylindolin- | US10100045, Example 21
Type:
Small organic molecule
Emp. Form.:
C19H17F3N4O
Mol. Mass.:
374.3597
SMILES:
CC(C)n1nc2ccc(nc2c1-c1cc2CC(=O)Nc2c(C)c1)C(F)(F)F
Structure:
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